Cross-talk between Histone Modifications in Response to Histone Deacetylase Inhibitors
نویسندگان
چکیده
منابع مشابه
Cross Talk between Histone Modifications in Response to Hdac Inhibitors: Mll4 Links Histone H3 Acetylation and Histone H3k4 Methylation
Histones are subject to a wide variety of posttranslational modifications, which play a central role in gene activation and silencing. We have used histone modification-specific antibodies to demonstrate that two histone modifications involved in gene activation – histone H3 acetylation, and H3 lysine 4 methylation – are functionally linked. This interaction, in which the extent of histone H3 a...
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Histone lysine acetylation is an epigenetic mark regulated by histone acetyltransferases and histone deacetylases (HDAC) which plays an important role in tumorigenesis. In this study, we observed a strong overexpression of class IIa HDAC9, at the mRNA and protein levels, in the most aggressive human breast cancer cell lines (i.e. in basal breast cancer cells vs luminal ones or in malignant vs b...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m606773200